|
rs1965673
|
|
|
0.700 |
GeneticVariation |
GWASDB |
Genome-wide association study identifies GIMAP as a novel susceptibility locus for Behcet's disease.
|
23041938 |
2013 |
|
rs7753873
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Concerning rs7753873, a higher frequency of the AC genotype (p (c) = 0.015, OR [95% CI] 1.49 [1.17-1.91]) and C allele (p (c) = 0.025, OR [95% CI] 1.39 [1.11-1.76]), and a lower frequency of the AA genotype (p (c) = 0.03, OR [95% CI] 0.68 [0.53-0.87]) and A allele (p (c) = 0.025, OR [95% CI] 0.72 [0.57-0.91]) were observed in BD patients.
|
23161053 |
2013 |
|
rs9494885
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The results showed a significantly increased prevalence of the rs9494885 TC genotype and C allele in BD patients compared with controls (Bonferroni corrected p (p (c)) = 1.83 × 10(-10), odds ratio (OR) [95% CI] 2.03 [1.65-2.49]; p (c) = 8.35 × 10(-10), OR [95% CI] 1.81 [1.51-2.18], respectively).The frequency of the TT genotype and T allele of rs9494885 was markedly lower in BD patients than that in controls (p (c) = 1.23 × 10(-10), OR [95% CI] 0.50 [0.40-0.61]; p (c) = 8.35 × 10(-10), OR [95% CI] 0.55 [0.46-0.66], respectively).
|
23161053 |
2013 |
|
rs2010963
|
|
|
0.010 |
GeneticVariation |
BEFREE |
All patients with BD and controls were genotyped by polymerase chain reaction and allele-specific oligonucleotide techniques for +936 C/T (rs3025039) and -634 C/G (rs2010963) mutations and for an 18 base pair (bp) insertion/deletion (I/D) polymorphism at -2549 of the the VEGF promoter region.
|
15338501 |
2004 |
|
rs1544410
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The clinical characteristics of BD patients were evaluated and patients with ocular lesions had a higher percentage of rs1544410 A alleles (p = 0.004), and patients with oral aphthous lesions, a positive pathergy tests, and arthritis had more rs2228570 C alleles than patients without these clinical findings (respectively, p < 0.001, p = 0.021, p = 0.045).
|
30730049 |
2019 |
|
rs228648
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that Thr21Met but not Ser89Asn polymorphisms of the UTS-II gene were markedly associated with the risk of developing BD (</span>p<0.0001), The Met21Met genotype was less common among BD patients (6.1% in patients vs. 17.1% in controls; p<0.0001).
|
23333481 |
2013 |
|
rs2890565
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that Thr21Met but not Ser89Asn polymorphisms of the UTS-II gene were markedly associated with the risk of developing BD (p<0.0001), The Met21Met genotype was less common among BD patients (6.1% in patients vs. 17.1% in controls; p<0.0001).
|
23333481 |
2013 |
|
rs4936742
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results showed that the UBASH3B gene rs4936742 (T > C) polymorphism is associated with an increased risk of Behcet's disease, especially non-ocular BD, in Iranian population.
|
30289285 |
2019 |
|
rs3825427
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The fine-mapping association study of UBAC2 identified six risk SNPs for BD in the Chinese cohort; three of them were verified in validation study (rs3825427, first-stage Pc = 2.2 × 10-3, second-stage Pc = 9.3 × 10-3, combined Pc = 6.9 × 10-6; rs9517668, first-stage Pc = 1.7 × 10-3, second-stage Pc = 0.03, combined Pc = 3.3 × 10-4; rs9517701, first-stage Pc = 5.1 × 10-3, second-stage Pc = 9.0 × 10-3, combined Pc = 2.9 × 10-5; respectively).
|
22455605 |
2012 |
|
rs7999348
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Indeed, we demonstrated that rs7999348 tags a functional variant associated with increased messenger RNA expression of a UBAC2 transcript variant in peripheral blood mononuclear cells of individuals homozygous for the Behçet's disease-associated "G" allele.
|
21918955 |
2011 |
|
rs9513584
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The first-stage study results showed that UBAC2 (rs9513584, Pc = 0.018, OR = 1.4), but not LOC100129342, KIAA1529, CPVL, UBASH3B was associated with the susceptibility to BD in Chinese Han.
|
22455605 |
2012 |
|
rs9517668
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The fine-mapping association study of UBAC2 identified six risk SNPs for BD in the Chinese cohort; three of them were verified in validation study (rs3825427, first-stage Pc = 2.2 × 10-3, second-stage Pc = 9.3 × 10-3, combined Pc = 6.9 × 10-6; rs9517668, first-stage Pc = 1.7 × 10-3, second-stage Pc = 0.03, combined Pc = 3.3 × 10-4; rs9517701, first-stage Pc = 5.1 × 10-3, second-stage Pc = 9.0 × 10-3, combined Pc = 2.9 × 10-5; respectively).
|
22455605 |
2012 |
|
rs9517701
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The fine-mapping association study of UBAC2 identified six risk SNPs for BD in the Chinese cohort; three of them were verified in validation study (rs3825427, first-stage Pc = 2.2 × 10-3, second-stage Pc = 9.3 × 10-3, combined Pc = 6.9 × 10-6; rs9517668, first-stage Pc = 1.7 × 10-3, second-stage Pc = 0.03, combined Pc = 3.3 × 10-4; rs9517701, first-stage Pc = 5.1 × 10-3, second-stage Pc = 9.0 × 10-3, combined Pc = 2.9 × 10-5; respectively).
|
22455605 |
2012 |
|
rs2234237
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that TREM-1 SNPs are significantly associated with the development of intestinal Behcet's disease (rs9471535: odds ratio [OR]=1.637, P=0.025; rs3789205: OR=1.668, P=0.019; rs2234237: OR=1.691, P=0.016), and in particular with skin involvement (rs9471535: OR=2.723, P=0.009; rs3789205: OR=2.477, P=0.017; rs2234237: OR=2.278, P=0.030) and the risk of azathioprine use (rs9471535: OR=2.722, P=0.021; rs3789205: OR=2.493, P=0.032; rs2234237: OR=2.638, P=0.026).
|
21763322 |
2011 |
|
rs3789205
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that TREM-1 SNPs are significantly associated with the development of intestinal Behcet's disease (rs9471535: odds ratio [OR]=1.637, P=0.025; rs3789205: OR=1.668, P=0.019; rs2234237: OR=1.691, P=0.016), and in particular with skin involvement (rs9471535: OR=2.723, P=0.009; rs3789205: OR=2.477, P=0.017; rs2234237: OR=2.278, P=0.030) and the risk of azathioprine use (rs9471535: OR=2.722, P=0.021; rs3789205: OR=2.493, P=0.032; rs2234237: OR=2.638, P=0.026).
|
21763322 |
2011 |
|
rs9471535
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that TREM-1 SNPs are significantly associated with the development of intestinal Behcet's disease (rs9471535: odds ratio [OR]=1.637, P=0.025; rs3789205: OR=1.668, P=0.019; rs2234237: OR=1.691, P=0.016), and in particular with skin involvement (rs9471535: OR=2.723, P=0.009; rs3789205: OR=2.477, P=0.017; rs2234237: OR=2.278, P=0.030) and the risk of azathioprine use (rs9471535: OR=2.722, P=0.021; rs3789205: OR=2.493, P=0.032; rs2234237: OR=2.638, P=0.026).
|
21763322 |
2011 |
|
rs10863888
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Three SNPs (rs6540679, rs12569232, rs10863888) of TRAF5 and rs13210247 of TRAF3IP2 were significantly associated with Behçet's disease and VKH syndrome (corrected P values ranging from 9.45×10(-12) to 0.027).
|
24416204 |
2014 |
|
rs13210247
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Three SNPs (rs6540679, rs12569232, rs10863888) of TRAF5 and rs13210247 of TRAF3IP2 were significantly associated with Behçet's disease and VKH syndrome (corrected P values ranging from 9.45×10(-12) to 0.027).
|
24416204 |
2014 |
|
rs2280714
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our study revealed that the rs2280714 and rs752637 SNPs were not associated with the susceptibility to BD.
|
19816589 |
2009 |
|
rs1234313
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The A allele and AA genotype frequencies of <i>TNFSF4</i>/rs1234313 were significantly increased, and the GG genotype frequency of rs1234313 was decreased in subjects with BD.
|
29285231 |
2017 |
|
rs1234315
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We observed a significantly increased frequency of the TT genotype of rs1234315 in BD patients (Pc = 1.44 × 10<sup>-5</sup>, OR = 1.734, 95% CI = 1.398-2.151).
|
27872495 |
2016 |
|
rs4246905
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Significantly lower frequencies of the C allele and the CC genotype and higher frequencies of the TT and CT genotypes of <i>TNFSF15</i>/rs4246905 were observed in BD patients.
|
29285231 |
2017 |
|
rs1061622
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In this study, we investigated genetic polymorphisms of TNF alpha -308 G/A, TNF beta +252 G/A, and TNFR2 196 R/M in 94 Korean BD patients and age- and sex-matched healthy controls to investigate the role of TNF and TNF receptor polymorphisms in BD.
|
12770792 |
2003 |
|
rs886039866
|
|
A |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs4149584
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The R92Q mutation in patients with Behçet's disease is associated with an increased risk of extracranial venous thrombosis.
|
15692984 |
2005 |